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Indirect Treatment Comparison/Network Meta-Analysis Study Questionnaire to Assess Relevance and Credibility to Inform Health Care Decision Making: An Ispor-Amcp-Npc Good Practice Task Force Report

Maintaining healthy L-carnitine levels is essential for skeletal and cardiac muscle function and, importantly, for maintaining mitochondrial health, which is important for healthy aging [7274].* In preclinical studies, it has been shown that L-carnitine insufficiency is associated with aging and compromised mitochondrial function and metabolic health [75].* L-carnitine and ALCAR supplementation may help to maintain healthy L-carnitine levels in tissues, support mitochondrial performance, and promote healthy aging [76,77]

Investigators use this higher-concentration formulation to evaluate prolonged receptor-crosstalk efficiency and metabolic homeostasis, rather than clinical efficacy, therapeutic outcomes, or disease treatment

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Rakipovski et al., 2018