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Long term consequences of prenatal exposure to gutkha were demonstrated in mice, where the adult male offspring exposed to a high fat diet developed histological evidence of non-alcoholic fatty liver disease in addition to significant alterations in hepatic fibrosis-related cytokines (interleukin (IL)-1b and IL-6) and in hepatic collagen mRNA expression levels compared to control (non-exposed) group (Doherty Lyons et al., 2020)
Substance Abuse and Mental Health Services Administration
Secondhand smoke is a significant public health concern
This would seem to suggest that "frequent" would be more often than in 1 in 100 patients and "rare" less than 1 in 1,000 patients
Gingiss PL, Gottlieb NH
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