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Retatrutide is a triple agonist (GIP, GLP-1, and glucagon receptors) while Ozempic activates only GLP-1 receptors, resulting in significantly greater weight loss, 24.2% versus 14.9% at standard doses

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Tirzepatide has real-world human outcomes

Insomnia often begins as a temporary disruption but can evolve into a self-perpetuating, chronic condition with cortical overactivation, limbic dysregulation, and hypothalamic-pituitary-adrenal (HPA) axis hypersensitivity