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Rates of hypoglycemia and GI intolerance were similar among the active-treatment groups, but body weight decreased in patients taking sitagliptin (0.4 kg) or placebo (0.8 kg) and increased in those taking rosiglitazone (+1.5 kg)
Patients often experience improved energy levels and overall health as they shed excess weight
Once inside the mitochondrial matrix, carnitine palmitoyltransferase II (CPT II) converts fatty acyl-carnitine back into fatty acyl-CoA, allowing beta-oxidation to proceed in experimental systems
Industry analysts project a potential launch in 2028, though timelines could shift depending on regulatory review
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