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These binuclear copper ions are connected to six histidine residues (His 61 , His 85 , His 94 , His 259 , His 263 , and His 296 residues), which further interact with the adjacent residues, viz

Results obtained from measuring cell viability are summarized in Fig

Thus, phase I reactions are usually oxidation, reduction, dealkylation, epoxidation, oxidative deamination reactions, etc., which are primarily catalyzed by enzymes of the cytochrome P450 (P450

To identify CXCL10-interacting proteins in the ovaries, the ovarian tissue of the mice was lysed in lysis buffer (Yeasen), and the ovarian lysate was incubated with CXCL10-bound glutathione agarose beads at 4 C for 4 h

Some researchers also suggest glutathione can directly bind with the active site of tyrosinase (which contains copper), effectively inactivating the enzyme and further halting melanin synthesis