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Vitamin B12 is vital for the production of red blood cells in the body and keeping the nervous system in check

Animal studies have reported observations of altered body composition and reduced adiposity in NNMT-inhibited models

This is especially important for women and anyone over 40, populations where muscle preservation during weight loss is critical for long-term metabolic health

According to the NICE Clinical Knowledge Summary (CKS) and the British National Formulary (BNF) , the standard treatment for B12 deficiency without neurological symptoms involves: Hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks Followed by maintenance doses of 1 mg every three months For patients with neurological symptoms (such as paraesthesia, numbness, cognitive changes, or gait disturbances), more intensive treatment is required: Hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs Followed by 1 mg every two months for maintenance Pernicious anaemia , an autoimmune condition where the body cannot produce intrinsic factor, requires lifelong treatment

Properly reconstituted and stored tirzepatide should remain clear and colorless for up to 28 days