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"IARC Monographs on the Identification of Carcinogenic Hazards to Humans"

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Nicotine disrupts the normal relationship between a neurotransmitter (chemical communicator) called acetylcholine (ACh) and the receptors that acetylcholine attaches to

145, 146 PGE 2 is increased in the airways of smokers and COPD patients in whom it exerts not only beneficial effects, through bronchodilatation and immunosuppression, but also negative effects by enhancing mucus secretion