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These changes were also associated with mitochondrial damage and an impaired oxidant/antioxidant balance [24,25,26], which is accompanied by excessive production of cellular ROS [27], increased pro-inflammatory responses and cellular senescence, all hallmarks of COPD [28,29,30]

The other group lost four bombers in a subsequent interception, but Stewart's decision possibly saved it from annihilation and incurred considerable damage to his own 48 aircraft

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You can see a longer version of this trend starting in the 1930s here, although the numbers differ from the ones shown here because theyre using a different reference population for age-standardization