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Orlistat (Xenical/Alli) works locally in the gut by blocking fat absorption rather than acting on appetite hormones at all

Sci Signal 2012

Refrigeration (2-8C / 36-46F): The Standard Protocol This is the sweet spot

In such systems, hydrophobic moieties aggregate to form the core, while hydrophilic polysaccharide chains constitute the shell, yielding stable micellar structures (224)