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There are a few factors that could contribute to someone failing a drug test due to secondhand cannabis smoke including: Low tolerance to cannabinoids or cannabis exposure Small body weight/size Inhaling secondhand smoke in a small, enclosed space What Happens When We Consume Cannabis When we consume cannabis, phytocannabinoids like cannabidiol (CBD), CBN, and delta-9 tetrahydrocannabinol (THC) interact with our bodys endocannabinoid receptors in the endocannabinoid system (ECS) a complex cell signaling network found throughout the body and the brain