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10.1186/s12979-018-0128-5 39 ZhongW.SuW.LiT.TanX.ChenC.WangQ.et al (2021)
While this can be beneficial for its intended therapeutic effects, it also raises the possibility of off-target effects
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There is also growing evidence that disruption of antioxidant systems in ferroptosis contributes to the anticancer treatment of several forms of drug-resistant solid tumors (Figure 2)
They measured the apparent levels of messenger RNA (mRNA) associated with urea cycle enzymes in the liver, evaluated the overall nitrogen balance, and hypothesized the nitrogen contents of various organs
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