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use the FDA-approved version You have a personal or family history of medullary thyroid carcinoma or MEN2 (absolute contraindication) You have a history of severe pancreatitis You have gastroparesis or severe gastrointestinal motility disorders You are pregnant, breastfeeding, or planning pregnancy within 2 months (semaglutide has a 5-week washout period) You are not willing to accept the uncertainty around compounded medication quality and the possibility of needing to switch to brand-name if the shortage resolves Consider tirzepatide (compounded or brand Zepbound) instead if: You tried semaglutide and had inadequate weight loss (tirzepatide produces 2-3% more weight loss on average) You had intolerable nausea on semaglutide (tirzepatide has a slightly different side-effect profile

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A: If you have Type 2 diabetes, you may be able to after you discuss this with your doctor

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