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The new frontier
The 6-8 week treatment duration often extends to 12 weeks for more severe TFCC tears
It could account for nearly half of the moisture loss in soil
Basic pharmacokinetic parameters including absorption, distribution, metabolism, and excretion characteristics in human subjects would inform rational dosing strategies and identify potential sources of pharmacokinetic variability affecting individual response
Pharmacokinetic studies in rats demonstrated an oral bioavailability of 38.4%, with a mean Cmax of 2,252 ng/mL and terminal elimination half-lives of 3.80 1.10 hours (IV) and 6.90 1.20 hours (oral) (Awosemo et al., 2021)
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