These observations highlight the need for large-scale, multicenter, randomized, placebo-controlled trials to ascertain whether targeted modulation of specific probiotic strains or other gut microbes associated with a lean phenotype can effectively counteract obesity and improve insulin sensitivity
Cho SK, Pedram A, Levin ER, Kwon YJ
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Myo-inositol effects in PCOS: meta-analysis of RCTs (Int J Endocrinol, 2016)Mixed randomized-trial support for oral myo-inositol on insulin-resistance markers in PCOS, at gram-level oral doses rather than injected MIC amounts