SGLT2 transporters are present in retinal cells, including mesangial cells and retinal pericytes [38], which may suggest that SGLT2i agents act in directly reducing glucose levels in the retinal microcirculation and hence reduce glucotoxicity, oxidative stress and inflammation, and restore insulin signalling, halting glucose-induced vascular and endothelial dysfunction, progression of microangiopathy and, importantly, diabetic retinopathy [7, 39]
Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jdar E, Leiter LA, Lingvay I, Rosenstock J, Seufert J, Warren ML
Then, at last years conference, he met Lee
Therapeutic effect of Reduced Glutathione on acute kidney injury in patients with sepsis
Prospero, L