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The compromised response to ovarian stimulation underscores the pervasive negative impact of smoking on various facets of the IVF process and female fertility more broadly

While appropriate engagement of well-regulated stress responses is central to the maintenance of physiological homeostasis, the persistent induction of unresolving BCEV-induced stress, particularly in smokers or E-cigarette users, may eventually be maladaptive in a manner that is ultimately conducive to tissue damage and/or recipient cell transformation

Side effects were similar between groups except for nausea, which affected 8.7% of NRT users versus 5.3% of placebo users

non-smokers 24 , and the striatum is widely considered to be a key set of brain structures that support addiction 25,26,27 , with interactions between nicotine and the mesolimbic dopamine system also well-established (for a review see 28 )