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In contrast, thyroxine (T4) may elicit pro-fibrotic effects through non-genomic signaling via integrin v3, activating Rho-dependent pathways that induce -SMA and p75 neurotrophin receptor (p75NTR) expression in HSCs (99)

*Frontiers in Pharmacology*, 12, 634151

Lewis Black took over the role for later seasons, with Santa appearing traditionally animated and for a Kamp Koral episode in CGI

316 Mutations in OXPHOS mtDNA lead to the inhibition of the respiratory chain, which can then increase the production of ROS and further enhance the mtDNA damage