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Selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants each influence appetite differently, and combining them with GLP-1 therapy may amplify appetite suppression or nausea in some patients

The combination also increases the risk of nausea and can further stress the GI tract during the window when side effects are already most likely

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In Tanzeum, albiglutide is lyophilized with mannitol (stabilizer/tonicity adjuster), trehalose dihydrate (stabilizer/tonicity adjuster), polysorbate 80 (surfactant), and sodium phosphate (pH adjuster)

Others maintain injections because they prefer the direct delivery and consistent results