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Mater 14 (10), e2403933

98 In addition, Muc2 gene mutation in mice can induce endoplasmic reticulum stress in intestinal epithelial cells, and the misfolding of intrinsic proteins in the intestinal epithelium triggers the inflammatory response of intestinal epithelial cells, thereby destroying the structure and function of the intestinal barrier in mice and promoting the progression of UC by affecting the intestinal microbiota

If there is barely any GH around to bind them, that second half of the mechanism never actually runs

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