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Accordingly, we performed several sensitivity analyses, and our findings remain the same when using 2-year cohort intervals, as well as alternate functional forms of age, indicating that these transformations make no substantive difference to the reported results 70,71

The permutation p-value was calculated as the number of permuted coefficients that were as or more extreme than our observed value

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Available at: www.lungusa.org/finding-cures/our-research/trend-reports/Tobacco-Trend-Report.pdf