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As the decline in smoking through the current regulations and taxations seem to be hitting a wall (declining from 19% to 14% between 2010 and 2018), regulators seeking a science-informed approach have focused on identifying a nicotine-addiction threshold

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We know what has to happen next: tobacco has given us the blueprint

Additionally, adverse childhood experiences, including maltreatment, cannabis consumption, and unfavorable living conditions during critical early life stages, have been shown were linked to an individuals vulnerability to subsequent depressive episodes [15,16,17,18,19]

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