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Clinical Evidence on Results From Combining Fat-Mobilizing and Appetite-Suppressing Treatments Individual tirzepatide trials (SURMOUNT-1, SURMOUNT-2, SURMOUNT-4) demonstrated average weight loss of 20.922.5% of baseline body weight over 68 weeks at the highest doses, with significant improvements in cardiometabolic markers including fasting glucose, triglycerides, and blood pressure

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