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Clinical Evidence: Several studies support the potential of BPC-157 in correcting calcium imbalance: a) A study published in the Journal of Orthopaedic Research demonstrated that BPC-157 administration improved bone healing and increased calcium deposition in rats with induced bone fractures, suggesting its positive effect on calcium metabolism

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The ensuing negative feedback loop may involve not only EECs but also Paneth cells and intestinal intraepithelial lymphocytes, as these cells have been reported to express the receptor for GLP-1 (namely GLP-1R), and loss of GLP-1R increases the severity of DSS-induced intestinal injury8, 9

its theoretical advantage (physiological sleep architecture modulation without sedation) has not been confirmed by adequately powered trials