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Myeloproliferative neoplasms (such as polycythaemia vera or chronic myeloid leukaemia) and acute leukaemias can increase B12-binding proteins (transcobalamins), raising total serum B12

Tumor redox heterogeneity, variations in intracellular GSH levels, and discrepancies between in vitro and in vivo redox environments make precise prediction of therapeutic activation difficult

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Interestingly, despite the particular susceptibility to damage to the photoreceptor layer observed in histopathological studies, the morphology of this layer in the reported OCT scans was normal (Koehrer et al

A gene modulator is a molecule that can interact with this system to restore a more favorable pattern of expression