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However, due to concerns for safety, quality, and effectiveness of compounded GLP1RAs, the American Diabetes Association (ADA) has issued guidance recommending switching individuals to different FDA-approved medications to achieve and maintain individualized glucose-lowering, weight management, and/or cardiovascular and kidney risk reduction goals when supply or access is limited [75]

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Eli Lilly has stated it plans to do so this year for orforglipron as an obesity treatment, and in 2026 for treating patients with diabetes