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Animals Adult male (n=68) and female (n=68) SpragueDawley rats were bred in house from breeding pairs obtained from Charles River, Quebec, Canada, after weaning rats were double-housed in a 12-h light/dark cycle

Pros: Modest weight loss (typically 5-10% of body weight) Can be used long-term Available without prescription in lower doses Cons: Gastrointestinal side effects Requires strict low-fat diet adherence May interfere with absorption of fat-soluble vitamins Phentermine (Adipex-P, Lomaira) Phentermine is an appetite suppressant that affects the central nervous system

It participates in the natural production of glutathione and in the synthesis of neurotransmitters that promote emotional balance and mental clarity

Liver enlargement is apparent after three days in rats (SchulteHermann and Parzefall 1980)