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Serine and glycine also charge the folate pool with one-carbon units, including N 10 -formyl-THF, that are ultimately used to produce nucleotides, methionine, and S-adenosylmethionine, the latter of which is the major methyl donor for methyltransferase reactions including those of DNA and histones [62, 63]

This signalling divergence IGF-1R-independent ERK activation vs IGF-1R-dependent Akt/mTOR activation is one of the central research questions in the MGF field and is the mechanistic basis for the functionally distinct roles of MGF (proliferation, satellite cell activation, anti-differentiation) and mature IGF-1 (differentiation, protein synthesis, hypertrophy) in the sequential muscle regeneration programme