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Zheng YF, Han XB, Zhao DL, Wei KK, Yuan Y, Li YQ, et al

We don't have the long-term studies to show the effects of COPD [chronic obstructive pulmonary disease] or cancer, but our concerns are that its very similar in the way that it took years for us to figure out that tobacco led to, with definite science, led to things like cancer and development of COPD, Rizzo added

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[34] In response, tobacco companies have argued that they have not intentionally made cigarettes more dangerous, but instead carefully and thoughtfully design the least hazardous tobacco product for smokers