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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome

For instance, GnRH from the hypothalamus stimulates pituitary secretion of LH and FSH, which act upon the ovaries and testes

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