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It is expressed on regulatory T cells, endothelial cells, oligodendrocyte lineage cells, and select neurons and can induce pro-survival signaling by procuring TRAF2 [28] and activating the PI3K/NF-B pathway [75,76,77,78], thereby protecting against excitotoxic and ischemic damage [75, 76] (Fig

The shrinking or wasting away of cells, organs, or tissues that may occur as part of a disease process, trauma, or aging