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How Carcinogens in Cigarette Smoke Cause Lung Cancer The carcinogens in cigarette smoke that are inhaled can be metabolically activated (most notably by cytochrome P450 enzymes in the liver) to intermediate compounds that covalently or (sometimes) directly bind to DNA

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Smoke curls gracefully from the cigarette, adding a dynamic element to the otherwise still and dramatic composition

Unlike smoking, which primarily affects the lungs, chewing tobacco delivers carcinogens directly to the tissues in the mouth, accelerating the development of oral cancers.A study published in Nature Communications reviewed global data on chewing tobacco use and its health effects

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