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Most of the nicotine in a cigarette is destroyed by combustion or remains in the sidestream smoke that you do not inhale

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References: Science Direct: Nicotine, its metabolism and an overview of its biological effects National Institute of Health (NIH): Nicotine Chemistry, Metabolism, Kinetics and Biomarkers NIH: Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

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