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Retailers in urban areas, especially large cities, may have higher prices due to the cost of doing business, while smaller towns or rural areas may see lower prices

Sympathetic nervous system activation (fight-or-flight) Nicotine can activate the sympathetic nervous system and increase catecholamine signaling, which may increase resting energy expenditure and activity-related energy expenditure (again described in the review on nicotines effects on energy balance)

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