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In case of smoke-induced cell death in human lung microvascular endothelial cells exposed to phosphate-buffered saline-conditioned cigarette smoke mimicking the exhaled cigarette smoke, the level of exposure was assessed by the increase in nicotine/cotinine levels, thus assessed cell injury and cell death was discussed in relation to the increase in nicotine/cotinine levels [14]

Exposure is linked to lung cancer, coronary disease, and respiratory symptoms among other health problems (US Department of Health and Human Services 2006)

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