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From a clinical perspective, reducing ZnT8 transport activity or down-regulating its cellular expression is proposed as an anti-diabetogenic strategy, mimicking the protective effect of SLC30A8 haploinsufficiency in humans

doi: 10.5713/ajas.17.0483 80 HajatiHZaghariMOliveiraHC

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1 Effect Allele: CT (+/-) You have the CT genotype for rs1799964, which means you carry one copy of the effect allele and one copy of the non-effect allele in the TNF gene