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Rather than acting on GLP-1, GIP or glucagon receptors, Cagrilintide mimics the naturally occurring hormone amylin, which is released alongside insulin after meals and plays an important role in regulating appetite, satiety and gastric emptying

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The former uses closely-spaced manometric sensors to measure the pressure profile and identifies pyloric activity by the combination of phasic and tonic contractions, as well as the combination of antral and duodenal phasic pressure activity in the manometric tracing (Vosoughi et al., 2020)

They concluded that incretin-based medications did not correlate with an increased risk of acute pancreatitis or pancreatic cancer compared to other oral anti-diabetic agents, which remained consistent across drug classification and duration of use [29,55]

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