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doi: 10.1002/jcp.30582 54 FengDZouJSuDMaiHZhangSLiPet al

GLP-1 medications such as Semaglutide and Tirzepatide mimic a natural hormone that regulates blood sugar, appetite, and digestion

GLP-1 receptor activation slows gastric emptying, which can cause variable bowel changes including looser stools, diarrhoea, or constipation

Besides, the protective effect of berberine resisting MTPT-induced toxicity may be related to the enhancement of autophagy by berberine through AMPK-dependent pathways (Deng and Ma, 2021)

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