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Abstract 1 -pyrroline-5-carboxylate synthetase ( P5CS ) is one of the key regulatory enzymes involved in the proline biosynthetic pathway

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Musculoskeletal arthralgias, aseptic necrosis of femoral and humeral heads, increase risk of fracture, loss of muscle mass, muscle weakness, myalgias, osteopenia, osteoporosis (see PRECAUTIONS: Musculoskeletal), pathologic fracture of long bones, steroid myopathy, tendon rupture (particularly of the Achilles tendon), vertebral compression fractures

In Wilson, John D

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