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The effect of PregS on AMPA receptor-mediated miniature excitatory post-synaptic current (mEPSC) frequency is blocked by lanthanide 3+ , a non-selective TRP channel blocker (155), providing support for TRPM3 as a target for PregS modulation of glutamate release

This lower retatrutide dose also means fewer GI side effects from the retatrutide itself, which is a meaningful quality-of-life improvement over the long term

(PubMed) Ellis J, Folkers K, Watanabe T, et al

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found that GLP-1R activation reduced tumor growth and metastatic potential by inhibiting ERK1/2 and AKT phosphorylation, lowering MMP-2 and MMP-9 expression, and increasing E-cadherin