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Research published in the New England Journal of Medicine (NEJM), shows that over a 40-week trial participants taking orforglipron reduced their glycated haemoglobin levels significantly more than those on a placebo

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Although GLP-1R agonists have yielded promising results in animal models, AD transgenic mice do not fully mimic the complex pathology of human AD, and there are still some challenges in translating them into effective AD therapies

However, upon exposure to specific signaling cues, cells can degrade ferritin through a selective autophagic process known as ferritinophagy (23)