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This localized delivery minimizes systemic absorption and potential side effects while maximizing the antifungal effect within the sinus cavities

10.1136/bjophthalmol-2021-319379 22

Option 3: Split Dosing (AM + Pre-Bed) For the 500mcg aod 9604 protocol, splitting into two doses can help maintain more consistent blood levels

Original Vial Seal and Integrity Research peptide vials are supplied with a tamper-evident seal over the rubber stopper

7-Dichlorofluorescin Diacetate (DCFDA) Assay for Production of Reactive Oxygen Species Cells were incubated in 10 M DCFDA (Sigma) in PBS at 37C for 30 min as previously described (Chiu et al., Quantification of 8-Hydroxy-2-Deoxyguanosine (8-OH-dG) as a Marker for Oxidative DNA Damage We used 8-Hydroxy-2-Deoxyguanosine (8-OH-dG) as a biomarker for oxidative DNA on brain cells exposed to different treatments using the commercially available HT 8-OH-dG ELISA II kit (R&D Systems) as guided by the manufacturers instructions