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NNMT slows down fat cell metabolism (which makes losing weight even more difficult.) By blocking NNMT, 5 Amino 1MQ can prevent this metabolism slow-down and promote weight loss

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In rodent knockout models where beta-3 adrenergic receptors were removed, the lipolytic response to AOD 9604 was eliminated, confirming the receptor-specific mechanism

Blocking NNMT is expected to raise SAM availability, but SAM participates in many cellular processes, so research must establish that selectively raising it does not perturb other methylation pathways