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Some metabolic peptides influence how the body regulates appetite, insulin sensitivity, and energy expenditure

Mar 16 2021;325(11):1043-1044

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Its typical mechanism involves VDR-mediated transcriptional activation of the Cathelicidin Antimicrobial Peptide (CAMP) gene, inducing the production of antimicrobial peptides, particularly cathelicidin LL-37 ( 2 D 3 induces expression of nucleotide-binding oligomerization domain 2 (NOD2), which upon activation by bacterial muramyl dipeptide stimulates NF-B signaling and subsequently induces human -defensin 2 ( DEFB2 /HBD2) expression, establishing Vitamin D 3 as both a direct and indirect regulator of antimicrobial peptide production ( 2 D 3 modulates the phenotype and function of monocyte and macrophage through multiple mechanisms: suppressing pro-inflammatory cytokine expression, including tumor necrosis factor (TNF)-, interleukin (IL)-1, IL-6, upregulating negative regulators such as mitogen-activated protein kinase (MAPK) phosphatase-1 ( 3 promotes the anti-inflammatory M2-like macrophage polarization through Peroxisome ProliferatorActivated Receptor (PPAR ) signaling pathways ( Figure 1C )