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Earlier SURMOUNT-1 data further reinforced these outcomes, with tirzepatide demonstrating weight loss of up to 22.5% of body weight over 72 weeks, the highest ever recorded for a pharmacological weight loss therapy at that time

The simplest possibility is that they enhance FBF recruitment of the Not1 deadenylase complex, a conserved mode of PUF repression from yeast to humans [7375]

doi: 10.1016/j.surg.2020.03.028, PMID: [DOI] [PubMed] [Google Scholar] 59

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