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Over time, repeated smoking creates a physical dependency, where instead of elation, the now addicted neural system begins to demand larger and larger amounts of nicotine just to maintain the same level of relative calm

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Also observed a significant increase in cytochrome P450 (CYP)-CYP1A1/2, CYP2B1/2 and CYP3A to an enhanced cancer risk from the widely bioactivated e-cig vapour procarcinogens associated with an increased risk of lung cancer with CYP induction and/or CYP polymorphisms (Table 3)

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