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Column 4 shows that combining the OPD fee schedule increase factor, along with the final changes in APC policy for CY 2026 and the final FY 2026 wage index updates, will result in an estimated increase of 2.1 percent

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Patients with severe renal or hepatic impairment whether dose adjustments or avoidance are necessary will depend on the pharmacokinetic data presented in the eventual retatrutide SmPC

And the FDA's April 30, 2026 proposal - if finalized after the June 29 comment deadline - would prohibit large-scale outsourcing facilities from compounding these molecules from bulk entirely, regardless of any future shortage

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