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This is one reason why GLP-1s are intended to be a long-term treatment whenever possible, as the effects can wear off once you discontinue use

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61 These maps were normalized against the whole brains mean of CBF to account for subject-level variation

Tirzepatide and semaglutide both mimic the effects of the gut hormone GLP-1, which stimulates the bodys production of insulin and slows the passage of food through the stomach