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Any potential transdiagnostic benefit of GLP-1RAs may be amplified by their established effects on cardiovascular and metabolic morbidity and mortality 21,22 , which are known to be raised in several cognitive and mental health disorders 244,245

The ruling is the latest in a series of high-profile disputes between major pharmaceutical manufacturers and compounding pharmacies over access to GLP-1 medications such as Mounjaro and Zepbound

During weight loss, particularly if dietary protein intake is insufficient (generally aim for 1.0-1.2g/kg/day unless contraindicated), there is a risk of losing lean muscle mass alongside fat tissue

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