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( Although the actual efficacy of Se in GO is uncertain, it is generally considered to be beneficial in the treatment of mildly active GO ( 3.2 Se and Hashimotos thyroiditis In recent years, the incidence of Hashimotos thyroiditis (HT) has been increasing with the wide application of thyroid ultrasound, fine needle puncture biopsy and other testing techniques

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The proposed enzymatic reaction sequence is highlighted with green arrows, whereas the generally proposed pathway is shown with an orange arrow