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Tier 2: BMI 30 or higher with a qualifying condition BMI 30 or higher, plus one specific condition

It is the major ingredient in both formulations

By elucidating this intricate pharmacological network, this review not only decodes the scientific basis for the nephroprotective effects of Rehmanniae Radix but also provides a theoretical foundation for the development of novel anti-fibrotic therapies and identifies promising molecular targets for future investigation

Gastrointestinal side effects represent the most common concern with both medications

These findings highlight the importance of maintaining continuous GLP-1 treatment to sustain cardiovascular benefits and indicate that strategies to reduce treatment discontinuity should be developed to maximize the cardioprotective effects of GLP-1s